Welcome to Topo.Bio

Topo.Bio is an integrated platform combining databases and computational tools dedicated to topological proteins. Here, you can explore the parallel universe of protein topology and utilize a variety of AI-assisted tools to design, analyze, and engineer novel protein topologies.

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Our Goals:

  • Discover and characterize naturally occurring topological proteins
  • Perform topological reengineering of linear proteins
  • Predict the structures of proteins with complex or unique topologies
  • De novo generate proteins with unprecedented topological architectures
  • Develop high-performance, multifunctional topological proteins